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In vitro expressed GPCR inserted in polymersome membranes for ligand-binding studies.
May, Sylvia; Andreasson-Ochsner, Mirjam; Fu, Zhikang; Low, Ying Xiu; Tan, Darren; de Hoog, Hans-Peter M; Ritz, Sandra; Nallani, Madhavan; Sinner, Eva-Kathrin.
Afiliación
  • May S; Patterning and Fabrication, Institute of Materials Research and Engineering, Agency for Science, Technology and Research, Singapore, Singapore.
Angew Chem Int Ed Engl ; 52(2): 749-53, 2013 Jan 07.
Article en En | MEDLINE | ID: mdl-23161746
ABSTRACT
The dopamine receptor D2 (DRD2), a G-protein coupled receptor is expressed into PBd(22)-PEO(13) and PMOXA(20)-PDMS(54)-PMOXA(20) block copolymer vesicles. The conformational integrity of the receptor is confirmed by antibody- and ligand-binding assays. Replacement of bound dopamine is demonstrated on surface-immobilized polymersomes, thus making this a promising platform for drug screening.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Receptores Acoplados a Proteínas G Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article País de afiliación: Singapur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Receptores Acoplados a Proteínas G Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article País de afiliación: Singapur