One-year observation of inflammatory markers in patients with aortic valve stenosis who expressed high or low Chlamydia pneumoniae antibody titers.
J Heart Valve Dis
; 21(5): 599-607, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-23167224
ABSTRACT
BACKGROUND AND AIM OF THE STUDY Aortic valve stenosis (AVS) and atherosclerosis can be regarded as two manifestations of the same pathological process. The study aim was to evaluate annually the plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) in AVS patients, and to compare these data in AVS patients with and without high IgG, IgM, and IgA titers against Chlamydia pneumoniae. METHODS:
Sixty patients with AVS who had declined the offer of remedial surgery were allocated to groups according to their antibody titers group A (n=30, high IgG titer), group B (n=30, low IgG titer), group C (n=22, high IgA titer), group D (n=38, low IgA titer), group E (n=7, high IgM titer), and group F (n=53, low IgM titer) Antibody titers, serum levels of inflammatory markers and echocardiographic scans were monitored at 12-month intervals.RESULTS:
During a one-year observation period, a greater number of patients in group A showed AVS deterioration compared to group B (p < 0.02). The mean IgA and IgM titers in group A were higher than in group B, while mean serum CRP and IL-6 levels, and IgG titer, tended to be higher in group C compared to group D. No statistically significant differences were identified in mean serum levels of CRP, IL-6, and TNFalpha between groups A and B.CONCLUSION:
The results of the study suggested a possible association between C. pneumoniae infection and the progression of AVS.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estenosis de la Válvula Aórtica
/
Proteína C-Reactiva
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Chlamydophila pneumoniae
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Heart Valve Dis
Asunto de la revista:
CARDIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Polonia