MTHFR gene polymorphisms are not involved in pancreatic cancer risk: a meta-analysis.
Asian Pac J Cancer Prev
; 13(9): 4627-30, 2012.
Article
en En
| MEDLINE
| ID: mdl-23167392
ABSTRACT
PURPOSE:
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been reported to be associated with pancreatic cancer, but the published studies have yielded inconsistent results. This study assessed the relationship between MTHFR gene polymorphisms and the risk for pancreatic cancer using a meta-analysis approach.METHODS:
A search of Google scholar, PubMed, Cochrane Library and CNKI databases before April 2012 was performed, and then associations of the MTHFR polymorphisms with pancreatic cancer risk were summarized. The association was assessed by odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was also calculated.RESULTS:
Four relative studies on MTHFR gene polymorphisms (C667T and A1298C) were included in this meta-analysis. Overall, C667T (TT vs. CCOR=1.61,95%CI=0.78-3.34; TT vs. CT OR=1.41,95%CI=0.88-2.25; Dominant modelOR=0.68,95%CI=0.40-1.17; Recessive model OR=0.82,95%CI=0.52-1.30) and A1298C (CC vs. AAOR=1.01,95%CI=0.47-2.17; CC vs. AC OR=0.99,95%CI=0.46-2.14; Dominant modelOR=1.01, 95%CI=0.47-2.20; Recessive model OR=1.01,95%CI=0.80-1.26) did not increase pancreatic cancer risk.CONCLUSIONS:
This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) are not associated with pancreatic cancer risk.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Polimorfismo Genético
/
Metilenotetrahidrofolato Reductasa (NADPH2)
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
China