[Genetic polymorphisms as tool indicators for individual vulnerability to smoking behaviour]. / Polimorfismos genéticos como indicadores de la vulnerabilidad individual a la adicción al tabaco.
Med Clin (Barc)
; 140(2): 49-52, 2013 Jan 19.
Article
en Es
| MEDLINE
| ID: mdl-23177301
ABSTRACT
BACKGROUND AND OBJECTIVES:
In line with genetic and pharmacological studies suggesting that neurotransmitter pathways play a role in nicotine dependence, research was conducted in connection with 4 genetic polymorphisms OPRM1, TPH1, ADRA2A and HTR1B. This study compares the genotype and allele frequencies in 3 groups (non-smokers, former smokers and smokers) of unrelated individuals (n=490) from Catalonia (north east Spain) in order to find any relationship. MATERIAL ANDMETHODS:
All polymorphisms were genotyped in each population group and statistical analysis was performed.RESULTS:
Data obtained show that there is a relationship between sex, age and the TPH1 locus, indicating a trend towards a lower frequency of the AA genotype in former smokers for the TPH1 locus.CONCLUSIONS:
The results indicate that a role is played by the TPH1 polymorphism as an indicator of therapeutic failure in smoking cessation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tabaquismo
/
Triptófano Hidroxilasa
/
Fumar
/
Polimorfismo de Nucleótido Simple
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
Es
Revista:
Med Clin (Barc)
Año:
2013
Tipo del documento:
Article