The combination of insulin and GLP-1 analogues in the treatment of type 2 diabetes.
Neth J Med
; 70(10): 436-43, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23230012
ABSTRACT
GLP-1 analogues have been proven to be effective in the treatment of type 2 diabetes mellitus. They stimulate insulin production and secretion, and suppress glucagon secretion, depending on the blood glucose level. They also have an effect on the brain, enhancing satiety, and on the gut, where they delay gastric emptying. Theoretically, in type 2 diabetes mellitus patients, the combination of a GLP-1 analogue with insulin seems attractive, because of the weight loss perceived in users of GLP-1 analogues in contrast to the weight gain seen in most patients starting insulin therapy, leading to even more insulin resistance. There are only a few randomised controlled trials which have studied this combination and several uncontrolled studies, which will be reviewed here.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
/
Péptido 1 Similar al Glucagón
/
Insulina
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
Neth J Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos