Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing.
Clin Pharmacol Ther
; 93(2): 153-8, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23232549
ABSTRACT
Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout. However, allopurinol is also one of the most common causes of severe cutaneous adverse reactions (SCARs), which include drug hypersensitivity syndrome, StevensJohnson syndrome, and toxic epidermal necrolysis. A variant allele of the human leukocyte antigen (HLA)-B, HLA-B*5801, associates strongly with allopurinolinduced SCAR. We have summarized the evidence from the published literature and developed peer-reviewed guidelines for allopurinol use based on HLA-B genotype.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos HLA-B
/
Alopurinol
/
Supresores de la Gota
/
Síndrome de Stevens-Johnson
Tipo de estudio:
Etiology_studies
/
Guideline
Límite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos