Metastatic melanoma presenting as polymorphic ventricular tachycardia.
Tex Heart Inst J
; 39(6): 890-3, 2012.
Article
en En
| MEDLINE
| ID: mdl-23304048
ABSTRACT
A 41-year-old woman with metastatic melanoma was admitted to the hospital because of syncopal episodes, which had developed after the administration of an experimental chemotherapy agent that targeted Notch signaling, as part of a phase I clinical trial. Cardiac monitoring revealed recurrent episodes of polymorphic ventricular tachycardia correlating with the patient's syncope. Investigations into the cause of the arrhythmia led to the discovery of metastatic lesions within the left ventricular myocardium. In presenting this case of polymorphic ventricular tachycardia as the antemortem clinical manifestation of metastatic melanoma involving the heart, we discuss the importance of recognizing that cardiac metastases can manifest themselves as arrhythmias in patients with malignant melanoma who are undergoing active anticancer treatment.
Palabras clave
Antineoplastic chemotherapy protocols/adverse effects; arrhythmias, cardiac/chemically induced/diagnosis/physiopathology/therapy; coronary disease/complications; heart neoplasms/pathology/secondary; melanoma/pathology; myocardium/pathology; receptors, notch/metabolism; recurrence/prevention & control; syncope/etiology; tachycardia, ventricular/chemically induced/etiology
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Taquicardia Ventricular
/
Electrocardiografía
/
Neoplasias Cardíacas
/
Melanoma
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Tex Heart Inst J
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos