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Chronic diazepam treatment in rats causes long-lasting changes in central [3H]-5-hydroxytryptamine and [14C]-gamma-aminobutyric acid release.
Hitchcott, P K; File, S E; Ekwuru, M; Neal, M J.
Afiliación
  • Hitchcott PK; Psychopharmacology Research Unit, UMDS, Guy's Hospital, London.
Br J Pharmacol ; 99(1): 11-2, 1990 Jan.
Article en En | MEDLINE | ID: mdl-2331565
The effects of chronic diazepam administration to rats on the central release of [3H]-5-hydroxytryptamine ([3H]-5-HT) and [14C]-gamma-aminobutyric acid ([14C]-GABA, ex vivo) were examined. Chronic (5 and 21 days) administration of diazepam (4 mg kg-1 i.p. daily for 21 days) reduced the K-evoked (20 mM KCl) release of [3H]-5-HT from frontal cortex by approximately 50%. Remarkably, this decrease was still present 1 week after diazepam withdrawal. Chronic diazepam treatment did not significantly affect hippocampal [3H]-5-HT release but after 21 days the K-evoked release of [14C]-GABA was more than doubled and remained elevated 30 h after withdrawal; it returned to control levels after 1 week, and decreased below control levels after 2 weeks. This study indicates that chronic diazepam treatment produces striking changes in transmitter release in rats that persist long after treatment has ceased.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Serotonina / Diazepam / Ácido gamma-Aminobutírico Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 1990 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Serotonina / Diazepam / Ácido gamma-Aminobutírico Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 1990 Tipo del documento: Article Pais de publicación: Reino Unido