Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.

Tanigina, E S; Semenikhina, A V; Popova, T N; Matasova, L V; Kryl'skiy, E D

Tanigina, E S; Semenikhina, A V; Popova, T N; Matasova, L V; Kryl'skiy, E D.

Afiliación

Tanigina ES; Department of Medical Biochemistry and Microbiology, Voronezh State University, Russia.

Bull Exp Biol Med ; 154(2): 192-5, 2012 Dec.

Article en En | MEDLINE | ID: mdl-23330122

ABSTRACT

ABSTRACT

Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.

Asunto(s)

Biguanidas/química; Biguanidas/uso terapéutico; Cardiotónicos/química; Cardiotónicos/uso terapéutico; Radicales Libres/metabolismo; Miocarditis/tratamiento farmacológico; Miocarditis/metabolismo; Animales; Homeostasis/efectos de los fármacos; Masculino; Ratas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biguanidas / Cardiotónicos / Radicales Libres / Miocarditis Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2012 Tipo del documento: Article País de afiliación: Rusia

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