Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles.
Lab Chip
; 13(6): 1109-13, 2013 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-23344502
ABSTRACT
An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría Raman
/
Urea
/
Técnicas Analíticas Microfluídicas
/
Nicotina
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Lab Chip
Asunto de la revista:
BIOTECNOLOGIA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania