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Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions.
Trovo, Marco; Roncadin, Mario; Polesel, Jerry; Piccoli, Erica; Mileto, Mario; Micheli, Elvia; Perin, Tiziana; Carbone, Antonino; Massarut, Samuele; Trovo, Mauro G.
Afiliación
  • Trovo M; Department of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, via F. Gallini 2, 33081 Aviano (PN), Italy. Electronic address: marcotrovo33@hotmail.com.
Breast ; 22(5): 744-7, 2013 Oct.
Article en En | MEDLINE | ID: mdl-23352319
PURPOSE: To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction). METHODS AND MATERIALS: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma. RESULTS: 77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively. CONCLUSIONS: 40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Neoplasias de la Mama / Carcinoma Ductal de Mama / Fraccionamiento de la Dosis de Radiación Tipo de estudio: Etiology_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2013 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Neoplasias de la Mama / Carcinoma Ductal de Mama / Fraccionamiento de la Dosis de Radiación Tipo de estudio: Etiology_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2013 Tipo del documento: Article Pais de publicación: Países Bajos