Tris reversibly inhibits secretion of albumin and alpha-1-antitrypsin at different sites.
FEBS Lett
; 263(2): 365-8, 1990 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-2335241
ABSTRACT
We have investigated the effect of the weak base Tris on the processing and secretion of albumin and alpha-1 antitrypsin by hepatocytes in culture. We show that the secretion of both proteins is 90% inhibited by 30 mM Tris. The post-synthetic processing of both proteins is inhibited to the same extent. These effects are completely reversible. Cell fractionation indicates that albumin accumulates in the Golgi, whereas alpha-1 antitrypsin fails to leave the endoplasmic reticulum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trometamina
/
Alfa 1-Antitripsina
/
Albúminas
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido