Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor.
J Virol
; 87(8): 4756-61, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23388720
Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Virales
/
Moléculas de Adhesión Celular
/
Virus de la Peste de los Pequeños Rumiantes
/
Acoplamiento Viral
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos