Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
Nat Genet
; 45(4): 415-21, 421e1-2, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23435085
ABSTRACT
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own â¼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vertebrados
/
Mapeo Cromosómico
/
Genoma
/
Evolución Molecular
/
Petromyzon
Límite:
Animals
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos