Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (Piaractus mesopotamicus).
J Vet Pharmacol Ther
; 36(6): 594-602, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23464606
ABSTRACT
Defining the pharmacokinetic parameters and depletion intervals for antimicrobials used in fish will help in the development of important guidelines for future regulations by Brazilian agencies on the use of these substances in fish farming. This paper presents a depletion study for enrofloxacin (ENR) and its main metabolite, ciprofloxacin (CIP), in pacu (Piaractus mesopotamicus) fillets. The depletion study was carried out under monitored environmental conditions, with the temperature controlled at 27 °C to mimic the fish farming conditions in Brazil. ENR was administered orally via medicated feed for 10 consecutive days at daily dosages of 10 mg/kg body weight (b.w.). The fish were slaughtered at 6, 12, and 24 h and 2, 3, 5, 8, 12, 17, and 24 days after the medication period. Considering a maximum residue limit of 100 µg/kg for the sum of the ENR and CIP residues in the fillet, the results obtained in the depletion study allowed the estimation of a half-life for ENR of 2.75 days and a withdrawal period of 23 days. The results obtained in this study are important for the farming of pacu in tropical regions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Residuos de Medicamentos
/
Fluoroquinolonas
/
Characiformes
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
J Vet Pharmacol Ther
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil