First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child.
J Clin Virol
; 57(2): 157-60, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23473961
ABSTRACT
BACKGROUND:
Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem.OBJECTIVES:
To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDYDESIGN:
Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment.RESULTS:
Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the disappearance of histological findings in support of lymphocytic myocarditis. Left ventricular assist device could be explanted. No adverse effects of Artesunate were noted.CONCLUSIONS:
In addition to existing heart failure treatments, Artesunate can be considered as an effective candidate for clinical use in cases of HHV-6B associated myocarditis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Herpesvirus Humano 6
/
Infecciones por Roseolovirus
/
Artemisininas
/
Miocarditis
Límite:
Humans
/
Infant
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia