[Staphylococcal cassette chromosome mec, evolution and genetic lines of methicillin resistant Staphylococcus aureus].
Antibiot Khimioter
; 57(9-10): 38-46, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-23477219
ABSTRACT
Methicillin resistant Staphylococcus aureus (MRSA) is the main pathogen of hospital- and community-associated infections. Methicillin resistance is due to mecA gene located in a mobile complex element, staphylococcal cassette chromosome mec (SCCmec). The structure of the staphylococcal cassettes is diverse. At present eleven types of the cassettes are described. Types I-IV SCCmec are always associated with epidemiologically significant genetic lines of Staphylococcus. Thus, the pandemic hospital-associated MRSA (HA MRSA) belonging to CC5 and CC8 are of the types I-III SCCmec. The prevalence of virulent community-associated MRSA (CA MRSA) in many regions of the world is first of all connected with the characteristics of the type IV SCCmec structure and the presence of a recently described arginine catabolic mobile element (ACME) increasing the colonization activity of Staphylococcus. The review presents the up-to-date data on the origin, genetic structure and classification of SCCmec. Global genetic lines of MRSA are described and the problem of CA MRSA is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Proteínas Bacterianas
/
Cromosomas Bacterianos
/
Evolución Molecular
/
Staphylococcus aureus Resistente a Meticilina
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Idioma:
Ru
Revista:
Antibiot Khimioter
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2012
Tipo del documento:
Article