Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B.
Pharmacol Biochem Behav
; 36(1): 89-95, 1990 May.
Article
en En
| MEDLINE
| ID: mdl-2349275
ABSTRACT
This study examined the effect of a specific M1 cholinergic agonist, AF102B, on place learning of aged and young rats. Spatial reference memory was tested in the Morris Water Maze task, while spatial working memory was tested on an 8-arm radial maze. Both memory functions were impaired in aged rats compared to young animals. However, the administration of AF102B significantly reduced the age-related cognitive impairments observed in both tasks. This data supports the assertion of the "cholinergic hypothesis," namely that specific enhancement of cholinergic function may reverse geriatric cognitive deficits.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parasimpaticomiméticos
/
Quinuclidinas
/
Tiofenos
/
Envejecimiento
/
Aprendizaje
/
Memoria
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1990
Tipo del documento:
Article