Identification of novel tumour-associated antigens in canine mammary gland tumour.
Vet Comp Oncol
; 13(3): 194-202, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-23510442
ABSTRACT
UNLABELLED Canine mammary gland tumour (MGT) is the most common neoplasm in female dogs and has similar biological characteristics to human MGT. Spontaneous canine MGT is a more attractive clinical model in oncological research than that of the murine experimental model. Tumour-associated antigens (TAAs), which are produced in tumour cells, are applied as tumour markers, tumour vaccine antigens and molecular targets of therapeutic drugs. In this study, we have primarily identified 13 different TAAs of canine MGT by serological immunoscreening of cDNA expression library. The results of serological mini-arrays of identified antigens showed that CCDC41 antigen specially reacted with 35% of sera from MGT-dogs and did not react with control sera. We also found that HSPH1 mRNA expression levels increased significantly in MGT tissues. These findings will contribute to the development of diagnostic technologies and translational target therapies for dogs. CLINICAL RELEVANCE HSPH1, which is strongly expressed in the tumour tissue, will be a possible vaccine antigen of canine MGT.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Carbohidratos Asociados a Tumores
/
Biomarcadores de Tumor
/
Neoplasias Mamarias Animales
/
Enfermedades de los Perros
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Vet Comp Oncol
Asunto de la revista:
MEDICINA VETERINARIA
/
NEOPLASIAS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón