Does giving segmental muscle vibration alter the response to botulinum toxin injections in the treatment of spasticity in people with multiple sclerosis? A single-blind randomized controlled trial.
Clin Rehabil
; 27(9): 803-12, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23543344
ABSTRACT
OBJECTIVE:
To determine if segmental muscle vibration and botulinum toxin-A injection, either alone or in combination, reduces spasticity in a sample of patients with multiple sclerosis.DESIGN:
Single-blind, randomized controlled trial.SETTING:
Physical medicine and rehabilitation outpatients service.SUBJECTS:
Forty-two patients affected by the secondary progressive form of multiple sclerosis randomized to group A (30 minutes of 120 Hz segmental muscle vibration over the rectus femoris and gastrocnemius medial and lateral, three per week, over a period of four weeks), group B (botulinum toxin in the rectus femoris, gastrocnemius medial and lateral and soleus, and segmental muscle vibration) and group C (botulinum toxin). MAINMEASURES:
Modified Ashworth Scale at knee and ankle, and Fatigue Severity Scale. All the measurements were performed at baseline (T0), 10 weeks (T1) and 22 weeks (T2) postallocation.RESULTS:
Modified Ashworth Scale at knee and ankle significantly decreased over time (p < 0.001) in all groups. Patients in group C displayed a significant increase of knee and ankle spasticity at T2 when compared with T1 (p < 0.05). Fatigue Severity Scale values in groups A and C were significantly higher at T0 [A 53.6 (2.31); C 48.5 (2.77)] than at either T1 [A 48.6 (2.21); p = 0.03; C 43.5 (3.22); p = 0.03] or T2 [A 46.7 (2.75); p = 0.02; 42.5 (2.17); p = 0.02], while no differences were detected in group B [T0 43.4 (3.10); T1 37.3 (3.15); T2 39.7 (2.97)].CONCLUSION:
Segmental muscle vibration and botulinum toxin-A reduces spasticity and improves fatigue in the medium-term follow-up in patients with multiple sclerosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vibración
/
Toxinas Botulínicas Tipo A
/
Esclerosis Múltiple
/
Espasticidad Muscular
/
Fármacos Neuromusculares
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Rehabil
Asunto de la revista:
REABILITACAO
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM