Involvement of the nucleus accumbens shell dopaminergic system in prelimbic NMDA-induced anxiolytic-like behaviors.
Neuropharmacology
; 71: 112-23, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23566820
ABSTRACT
BACKGROUND:
Nucleus accumbens (NAc) and prefrontal cortex (PFC) dopaminergic and glutamatergic systems are involved in fear/anxiety-related behaviors; meanwhile NAc dopaminergic system activity is mediated by PFC via NAc glutamatergic projections. This study has investigated the involvement of NAc shell dopaminergic system in prelimbic NMDA-induced anxiolytic-like behaviors.METHOD:
Elevated plus-maze apparatus was employed to test parameters of anxiety-like behaviors in male Wistar rats.RESULTS:
Unilateral intra-prelimbic injection of NMDA (0.9 µg/µl) but not D-AP7 (NMDA receptor antagonist; 0.25, 0.5 and 1 µg/µl) induced anxiolytic-like behaviors which was blocked by D-AP7. Moreover, unilateral infusion of SCH23390 (dopamine D1 receptor antagonist; 0.25, 0.5 and 1 µg/µl) and quinpirole (dopamine D2 receptor agonist; 0.125, 0.25 and 0.5 µg/µl) into the left NAc shell, did not alter anxiety-like behaviors. However, injection of SKF38393 (dopamine D1 receptor agonist; 3 µg/µl) and sulpiride (dopamine D2 receptor antagonist; 0.4 and 0.6 µg/µl) into the left NAc shell, likewise induced anxiolytic-like behaviors which were blocked by SCH23390 (0.25 µg/µl) and SKF96365 (Ca-channel blocker; 0.125 µg/µl)/SCH23390 (0.25 µg/µl), respectively. Furthermore, infusion of the subthreshold dose of SCH23390 (0.25 µg/µl) or quinpirole (0.25 µg/µl) into the left NAc shell, reduced while did not alter intra-prelimbic NMDA-induced anxiolytic-like behaviors, respectively. In addition, intra-NAc shell administration of the subthreshold dose of SKF38393 (1 µg/µl) or sulpiride (0.2 µg/µl), potentiated the lower dose response, while decreased the higher dose intra-left prelimbic NMDA response.CONCLUSION:
Our results suggested a modulatory effect of the NAc shell dopaminergic system on prelimbic NMDA-induced anxiolytic-like behaviors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Dopamina
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Receptores Dopaminérgicos
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Modelos Animales de Enfermedad
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Neuronas Dopaminérgicas
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Proteínas del Tejido Nervioso
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Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Año:
2013
Tipo del documento:
Article
País de afiliación:
Irán