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Depressive symptoms and circadian activity rhythm disturbances in community-dwelling older women.
Maglione, Jeanne E; Ancoli-Israel, Sonia; Peters, Katherine W; Paudel, Misti L; Yaffe, Kristine; Ensrud, Kristine E; Tranah, Greg J; Stone, Katie L.
Afiliación
  • Maglione JE; Department of Psychiatry, University of California, San Diego, La Jolla, CA.
  • Ancoli-Israel S; Department of Psychiatry, University of California, San Diego, La Jolla, CA; Department of Medicine, University of California, San Diego, La Jolla, CA.
  • Peters KW; California Pacific Medical Center Research Institute, San Francisco, CA.
  • Paudel ML; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN.
  • Yaffe K; Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, CA.
  • Ensrud KE; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN.
  • Tranah GJ; California Pacific Medical Center Research Institute, San Francisco, CA.
  • Stone KL; California Pacific Medical Center Research Institute, San Francisco, CA. Electronic address: kstone@sfcc-cpmc.net.
Am J Geriatr Psychiatry ; 22(4): 349-61, 2014 Apr.
Article en En | MEDLINE | ID: mdl-23567424
OBJECTIVES: Aging is associated with changes in circadian rhythms. Current evidence supports a role for circadian rhythms in the pathophysiology of depression. However, little is known about the relationship between depressive symptoms and circadian activity rhythms in older adults. We examined this association in community-dwelling older women. METHODS: We performed a cross-sectional analysis of 3,020 women (mean age: 83.55 ± 3.79 years) enrolled in the Study of Osteoporotic Fractures. Depressive symptoms were assessed with the Geriatric Depression Scale categorizing participants as "normal" (0-2; referent group, N = 1,961), "some depressive symptoms" (3-5, N = 704), or "depressed" (≥6, N = 355). Circadian activity rhythm variables were measured using wrist actigraphy. RESULTS: In age-adjusted and Study of Osteoporotic Fractures site-adjusted models, greater levels of depressive symptoms were associated with decreased amplitude (height; df = 3,014, t = -11.31, p for linear trend <0.001), pseudo F-statistic (robustness; df = 3,014, t = -8.07, p for linear trend <0.001), and mesor (mean modeled activity; df = 3014, t = -10.36, p for linear trend <0.001) of circadian activity rhythms. Greater levels of depressive symptoms were also associated with increased odds of being in the lowest quartile for amplitude (df = 1, χ(2) = 9240, p for linear trend <0.001), pseudo F-statistic (df = 1, χ(2) = 49.73, p for linear trend <0.001), and mesor (df = 1, χ(2) = 81.12, p for linear trend <0.001). These associations remained significant in multivariate models. Post-hoc analyses comparing mean amplitude, mesor, and pseudo F-statistic values pair-wise between depression-level groups revealed significant differences between women with "some depressive symptoms" and the "normal" group. CONCLUSION: These data suggest a graded association between greater levels of depressive symptoms and more desynchronization of circadian activity rhythms in community-dwelling older women. This association was observed even for women endorsing subthreshold levels of depressive symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Trastornos Cronobiológicos / Depresión Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Am J Geriatr Psychiatry Asunto de la revista: GERIATRIA / PSIQUIATRIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Trastornos Cronobiológicos / Depresión Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Am J Geriatr Psychiatry Asunto de la revista: GERIATRIA / PSIQUIATRIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido