Efficacy of tigecycline alone and in combination with gentamicin in the treatment of experimental endocarditis due to linezolid-resistant Enterococcus faecium.
Antimicrob Agents Chemother
; 57(7): 3392-4, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23587961
ABSTRACT
We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8-log10-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gentamicinas
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Infecciones por Bacterias Grampositivas
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Enterococcus faecium
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Endocarditis Bacteriana
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Minociclina
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Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2013
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
/
EUA
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UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA