Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-κB pathway.
FEBS Lett
; 587(10): 1556-61, 2013 May 21.
Article
en En
| MEDLINE
| ID: mdl-23597671
ABSTRACT
MicroRNA-21 and programmed cell death 4 (PDCD4), a downstream target of miR-21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages. These effects were abrogated by inhibitors of ERK1/2, JNK or NF-κB. Conditioned media collected from gAcrp-stimulated RAW 264.7 macrophages caused similar effects as direct gAcrp treatment, showing the paracrine effect of gAcrp. These data indicate that gAcrp modulates the miR-21/PDCD4 axis through the ERK and JNK/NF-κB pathways in RAW 264.7 macrophages and further suggest that the miR-21/PDCD4 axis may be a novel target mediating adiponectin-induced biological responses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al ARN
/
Sistema de Señalización de MAP Quinasas
/
MicroARNs
/
Adiponectina
/
Proteínas Reguladoras de la Apoptosis
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2013
Tipo del documento:
Article