Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by ß-lactamase.
Chem Commun (Camb)
; 49(42): 4791-3, 2013 May 25.
Article
en En
| MEDLINE
| ID: mdl-23603842
ABSTRACT
Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3'-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme ß-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Azo
/
Beta-Lactamasas
/
Profármacos
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Cefalosporinas
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Donantes de Óxido Nítrico
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Antibacterianos
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia