Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.
J Pharmacol Toxicol Methods
; 68(1): 88-96, 2013.
Article
en En
| MEDLINE
| ID: mdl-23624022
Palabras clave
AP (D); Action Potential (Duration); Action potential; Cardiac safety; Compound screening; Concentration for 50% Inhibition; ECG; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; I(Kr); I(Ks); IC(50); ICH; International Conference for Harmonization; Ion channels; Mathematical model; Methods; QSAR; QT interval; Quantitative Structure Activity Relationship; Rabbit ventricular wedge; TdP; Torsades de Pointes; electrocardiogram; hERG; human-Ether-a-go-go Related Gene; minus log(10) of IC(50); pIC(50); rapid delayed rectifier potassium current; slow delayed rectifier potassium current
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Simulación por Computador
/
Síndrome de QT Prolongado
/
Diseño de Fármacos
/
Modelos Teóricos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Animals
Idioma:
En
Revista:
J Pharmacol Toxicol Methods
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido