Topical diacerein for epidermolysis bullosa: a randomized controlled pilot study.
Orphanet J Rare Dis
; 8: 69, 2013 May 07.
Article
en En
| MEDLINE
| ID: mdl-23651789
ABSTRACT
Blistering in epidermolysis bullosa simplex type Dowling-Meara (EBS-DM) is associated with an inflammatory phenotype, which can be disrupted by diacerein in vitro. In this pilot study we hypothesized, that a topical formulation of diacerein 1% reduces blistering. Five patients initially applied diacerein underneath both armpits. Then, each participant received 1% diacerein-cream for one armpit, and placebo for the other (randomized withdrawal). The number of blisters was reduced significantly (left -78%; right -66% of baseline) within two weeks and remained significantly below the initial level even during withdrawal in four patients. These findings point to a relevant effect of diacerein and provide important information for a confirmative study.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epidermólisis Ampollosa Simple
/
Antraquinonas
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Antiinflamatorios
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Child
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Humans
/
Middle aged
Idioma:
En
Revista:
Orphanet J Rare Dis
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Austria