Patterning of regional gene expression in autism: new complexity.
Sci Rep
; 3: 1831, 2013.
Article
en En
| MEDLINE
| ID: mdl-23665920
ABSTRACT
Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains. It is unknown if regional de-differentiation occurs elsewhere in autistic brain. Using high resolution, genome-wide RNA expression microarrays and brain specimens meeting stringent selection criteria we evaluated gene expression data of two other regions Brodmann area 19 (occipital cortex) and cerebellar cortex. In contrast to frontal/temporal cortical data, our data do not indicate an attenuation of regional specialization between occipital and cerebellar cortical regions in autistic brains.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Autístico
/
Lóbulo Temporal
/
Encéfalo
/
Biomarcadores
/
Corteza Cerebral
/
Perfilación de la Expresión Génica
/
Lóbulo Frontal
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos