[Analysis of treatment and prognosis in 34 patients with anorectal malignant melanoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 16(5): 459-62, 2013 May.
Article
en Zh
| MEDLINE
| ID: mdl-23696404
ABSTRACT
OBJECTIVE:
To explore the prognostic factors of anorectal malignant melanoma (ARMM).METHODS:
Medical records and follow-up data of 34 patients with ARMM treated in the Chinese PLA General Hospital from March 1993 to November 2011 were analyzed retrospectively.RESULTS:
There were 26 abdominoperineal resections(APR) and 8 wide local excisions (WLE). Twenty patients underwent postoperative adjuvant therapy, including chemotherapy in 14 cases, radiotherapy in 2 cases, traditional Chinese medicine therapy in 4 cases and immunotherapy in 16 cases. Postoperative follow-up was carried out in all the patients and the mean follow-up period was 27 months. The 1-, 3- and 5-year overall survival rates were 76.3%, 39.6% and 20.6% respectively, while the 1-, 3- and 5-year disease-free survival rates were 60.6%, 30.8% and 12.8% respectively. APR and postoperative immunotherapy could significantly reduce the local recurrence rate. According to the Kaplan-Meier method, gross type of tumor, mural involvement, lymph metastasis, and clinical staging had significant effects on overall survival, while lymph metastasis and postoperative immunotherapy on disease-free survival. Cox proportional hazards model indicated that the clinical staging and postoperative immunotherapy were significant predictive factors.CONCLUSIONS:
Early diagnosis and correct choice of surgical method are the keys to the treatment. Postoperative immunotherapy can prolong disease-free survival.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanoma
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Wei Chang Wai Ke Za Zhi
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China