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Liver iron quantification by 3 tesla MRI: calibration on a rabbit model.
Peng, Peng; Huang, Zhongkui; Long, Liling; Zhao, Fanyu; Li, Chunyan; Li, Wenmei; He, Taigang.
Afiliación
  • Peng P; Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
J Magn Reson Imaging ; 38(6): 1585-90, 2013 Dec.
Article en En | MEDLINE | ID: mdl-23704041
PURPOSE: To determine the feasibility of liver iron quantification by 3 Tesla (T) MRI using a novel iron overload rabbit model. MATERIALS AND METHODS: Forty-two rabbits underwent iron dextran loading from 1 to 15 weeks. MRI signal intensity ratio (SIR) was measured using a gradient-echo sequence, and R2(1/T2) measured using an eight-echo spin-echo sequence at 3T. Ex vivo hepatic pathology was obtained for all rabbits studied. Postmortem assessments of liver iron concentration (LIC) were conducted in an atomic absorption spectrophotometer. MRI measures were fitted against LIC using linear regression for 30 of the iron-loaded rabbits. The remaining 12 iron-loaded rabbits were used to test the prediction accuracy of the derived models. RESULTS: LIC was linearly correlated to both liver-to-muscle SIR (r = -0.845) and R2 (r = 0.965) in a range achieved in this study (LIC < 10 mg/g dry tissue) at 3T. By regression, the linear equations were determined as: Y1 = 10.581-5.924X1 (Y1 : LIC, X1 :SIR); Y2 = -1.273+0.103X2 (Y2 :LIC, X2 :R2). In the 12 test rabbits, the predicted LICs using the derived equations agreed well with the results obtained using the spectrophotometer. CONCLUSION: Both SIR and R2 are highly correlated with LIC in a novel rabbit model. MRI quantification of liver iron overload is feasible at 3T.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algoritmos / Imagen por Resonancia Magnética / Sobrecarga de Hierro / Hierro / Hígado / Hepatopatías Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2013 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algoritmos / Imagen por Resonancia Magnética / Sobrecarga de Hierro / Hierro / Hígado / Hepatopatías Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2013 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos