Your browser doesn't support javascript.
loading
Vascular endothelial growth factor as a biomarker for endostatin gene therapy.
Braga, Marina Souza; Turaça, Thiago Lauro; Foguer, Karen; Chaves, Karen Cristina Barbosa; Pesquero, João Bosco; Chammas, Roger; Schor, Nestor; Bellini, Maria Helena.
Afiliación
  • Braga MS; Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil.
Biomed Pharmacother ; 67(6): 511-5, 2013 Jul.
Article en En | MEDLINE | ID: mdl-23726969
Renal cell carcinoma (RCC) is characterized by high vascular endothelial growth factor (VEGF) production and, consequently, excessive angiogenesis. Several strategies have been developed to target angiogenesis as a method for treating metastatic RCC (mRCC). Endostatin (ES) is a C-terminal fragment of collagen XVIII that has antiangiogenic activity. The aim of this study was to investigate the predictive value of circulating VEGF-A in a murine model of mRCC after ES gene therapy. ES therapy did not affect the levels of collagen XVIII/ES or ES in the tissue. The circulating level of ES was increased in the control and ES-treated groups (normal vs. control, P<0.05 and ES-treated vs. control, P<0.001), and the intratumoral vessels were significantly decreased (ES-treated vs. control, P<0.05). ES therapy decreased the VEGF mRNA levels. The tissue and circulating levels of VEGF in the control group were significantly higher than normal (P<0.01 and P<0.05, respectively). Treatment with ES significantly reduced the VEGF concentrations in both compartments (P<0.001 for tissue and P<0.05 for plasma). Our findings indicate that in addition to the directly targeted tumor vessels, ES exerts its antitumor effect by down-regulating VEGF gene expression in renal tumor cells. Additionally, our findings point to the predictive value of VEGF for ES therapy.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Biomarcadores de Tumor / Endostatinas / Factor A de Crecimiento Endotelial Vascular / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2013 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Biomarcadores de Tumor / Endostatinas / Factor A de Crecimiento Endotelial Vascular / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2013 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Francia