Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome.
Int J Pediatr Otorhinolaryngol
; 77(8): 1244-7, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23746417
ABSTRACT
OBJECTIVES:
Obstructive sleep apnoea syndrome (OSAS) is a common disorder in children, which is associated with enhanced inflammatory status. Inflammation-associated changes could be monitored by the assessment of exhaled biomarker profile. This study aimed to compare the exhaled biomarker profile in children with OSAS and habitual snorers.METHODS:
Eighteen children with OSAS (8 ± 2 years, mean ± SD) and ten non-OSAS subjects with habitual snoring (9 ± 2 years) were recruited. Exhaled breath was collected from the lower airways, processed using an electronic nose (E-nose) and analyzed off-line using principal component analysis, followed by discrimination analysis and logistic regression to build a receiver operating characteristic (ROC) curve.RESULTS:
Exhaled biomarker pattern of OSAS patients was discriminated from that of control subjects (p = 0.03, cross-validation accuracy 64%), ROC curve analysis (area 0.83) showed 78% sensitivity and 70% specificity.CONCLUSIONS:
The altered exhaled biomarker pattern in OSAS might reflect accelerated airway and/or systemic inflammation in diseased state. Breath pattern analysis by an E-nose can serve as a new tool to monitor inflammation in children with OSAS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apnea Obstructiva del Sueño
/
Espiración
/
Compuestos Orgánicos Volátiles
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Hungria