Integrating human pluripotent stem cells into drug development.
Cell Stem Cell
; 12(6): 669-77, 2013 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-23746976
ABSTRACT
Integration of physiologically relevant in vitro assays at the earliest stages of drug discovery may improve the likelihood of successfully translating preclinical discoveries to the clinic. Assays based on in vitro-differentiated, human pluripotent stem cell (IVD hPSC)-derived cells, which may better model human physiology, are starting to impact the drug discovery process, but their implementation has been slower than originally anticipated. In this Perspective, we discuss imperatives for incorporating IVD hPSCs into drug discovery and the associated challenges.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre Pluripotentes
/
Descubrimiento de Drogas
Límite:
Humans
Idioma:
En
Revista:
Cell Stem Cell
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos