Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?
Crit Care
; 17(3): 311, 2013 May 29.
Article
en En
| MEDLINE
| ID: mdl-23751085
ABSTRACT
Derangement of nitric oxide (NO) metabolism represents one of the key mechanisms contributing to macro- and microcirculatory failure in sepsis. Sepsis-related therapy combining fluid resuscitation with administration of vasopressor and inotropic agents, however, does not guarantee correction of maldistributed nutritive perfusion between and within organs. Therefore, the differentiated and selective pharmacologic modulation of NO-mediated vascular function could play a useful role in hemodynamic management of patients with sepsis. This viewpoint carefully evaluates the potential role of intentionally using partially opposing effects of NO donors and NO synthase inhibitors to complement current therapy of hemodynamic stabilization in patients with sepsis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sepsis
/
Óxido Nítrico
Límite:
Humans
Idioma:
En
Revista:
Crit Care
Año:
2013
Tipo del documento:
Article