[Influence of hypoxen on acetylsalicylic acid efficiency in acute inflammation].

ABSTRACT

Rats were treated by subplantar injections of 0.1 ml 1% carrageenan solution. In 3 hours, this led to the development of acute inflammatory reaction (swelling of legs, neutrophilic leukocytosis, increased erythrocyte sedimentation rate, activation of free-radical oxidation). Acetylsalicylic acid in a dose of 100 mg/kg reduced development of the inflammatory response. Hypoxen in a dose of 50 mg/kg potentiated the effect of acetylsalicylic acid. The injection of both hypoxen and acetylsalicylic acid before the injection of carrageenan produced a strong anti-inflammatory effect, which was manifested by a reliable decrease in all monitored signs of inflammation.