Pathologic correlation of serum carcinoembryonic antigen and cytokeratin 19 fragment in resected nonsmall cell lung cancer.
Korean J Thorac Cardiovasc Surg
; 46(3): 192-6, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23772406
ABSTRACT
BACKGROUND:
This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS ANDMETHODS:
The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression.RESULTS:
The mean serum CEA and Cyfra 21-1 levels prior to surgery were 6.8±23.1 mg/dL (range, 0.01 to 390.8 mg/dL) and 5.4±12.3 mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1 ß=8.463, p=0.010) and N stage (N2/3 vs. N0 ß=9.208, p<0.001) and histology (adenocarcinoma vs. squamous cell ß=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (ß=2.579, p<0.001) and histology (squamous cell vs. adenocarcinoma ß=4.420, p=0.020).CONCLUSION:
Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Korean J Thorac Cardiovasc Surg
Año:
2013
Tipo del documento:
Article