Overshadowing as prevention of anticipatory nausea and vomiting in pediatric cancer patients: study protocol for a randomized controlled trial.
Trials
; 14: 103, 2013 Apr 20.
Article
en En
| MEDLINE
| ID: mdl-23782493
ABSTRACT
BACKGROUND:
Emesis and nausea are side effects induced by chemotherapy. These effects lead to enormous stress and strain on cancer patients. Further consequences may include restrictions in quality of life, cachexia or therapy avoidance. Evidence suggests that cancer patients develop the side effects of nausea and vomiting in anticipation of chemotherapy. Contextual cues such as smell, sounds or even the sight of the clinic may evoke anticipatory nausea and vomiting prior to infusion. Anticipatory nausea and vomiting are problems that cannot be solved by administration of antiemetica alone.The purpose of the proposed randomized placebo-controlled trial is to use an overshadowing technique to prevent anticipatory nausea and vomiting and to decrease the intensity and duration of post-treatment nausea and vomiting. Furthermore, the effect on anxiety, adherence and quality of life will be evaluated. METHODS/DESIGN:
Fifty-two pediatric cancer patients will be evenly assigned to two groups an experimental group and a control group. The participants, hospital staff and data analysts will be kept blinded towards group allocation. The experimental group will receive during three chemotherapy cycles a salient piece of candy prior to every infusion, whereas the control group will receive flavorless placebo tablets.DISCUSSION:
If an effectiveness of the overshadowing technique is proven, implementation of this treatment into the hospitals' daily routine will follow. The use of this efficient and economic procedure should aid a reduced need for antiemetics. TRIAL REGISTRATION Current Controlled Trials ISRCTN30242271/
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proyectos de Investigación
/
Dulces
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Vómito Precoz
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Condicionamiento Clásico
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Señales (Psicología)
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Aprendizaje Discriminativo
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Náusea
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Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Guideline
Aspecto:
Patient_preference
Límite:
Adolescent
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Child
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Child, preschool
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Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Trials
Asunto de la revista:
MEDICINA
/
TERAPEUTICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania