Integrins in mechanotransduction.
Curr Opin Cell Biol
; 25(5): 613-8, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23797029
ABSTRACT
Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Integrinas
/
Adhesión Celular
/
Mecanotransducción Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos