Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation.
J Dent
; 41(9): 809-17, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23810851
ABSTRACT
OBJECTIVE:
To investigate the inhibitory effects of 38% silver diamine fluoride (SDF) on demineralised dentine.METHODS:
Human dentine blocks were demineralised and allocated to four groups SF, F, S and W. The blocks in group SF received a topical application of 38% SDF solution (253,900ppm Ag, 44,800ppm F), group F received a 10% sodium fluoride solution (44,800ppm F), group S received a 42% silver nitrate solution (253,900ppm Ag) and group W received deionised water (control). They were subjected to pH cycling using demineralisation solution (pH 5) and remineralisation solution (pH 7) for 8 days. The surface morphology, crystal characteristics, lesion depth and collagen matrix degradation of the specimens were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), micro-CT testing and spectrophotometry with a hydroxyproline assay.RESULTS:
The surface morphology under SEM showed evident demineralisation with exposed collagen in groups S and W, but not in group SF. Clusters of granular spherical grains were observed in the cross-sections of specimens in groups SF and F. XRD revealed precipitates of silver chloride in groups SF and S. The mean lesion depths (±SD) of groups SF, F, S and W were 182 ± 32µm, 204 ± 26µm, 259 ± 42µm and 265 ± 40µm, respectively (SDF, FCONCLUSION:
The use of 38% SDF inhibited demineralisation and preserved collagen from degradation in demineralised dentine. CLINICALSIGNIFICANCE:
SDF application positively influences dentine remineralization.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cariostáticos
/
Colágeno
/
Desmineralización Dental
/
Dentina
/
Compuestos de Amonio Cuaternario
Límite:
Humans
Idioma:
En
Revista:
J Dent
Año:
2013
Tipo del documento:
Article
País de afiliación:
Hong Kong