The utility of stool cultures for diagnosing tuberculosis in people living with the human immunodeficiency virus.
Int J Tuberc Lung Dis
; 17(8): 1023-8, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23827025
ABSTRACT
BACKGROUND:
Delayed diagnosis of tuberculosis (TB) increases mortality.OBJECTIVE:
To evaluate whether stool culture improves the diagnosis of TB in people living with the human immunodeficiency virus (PLHIV).DESIGN:
We analysed cross-sectional data of TB diagnosis in PLHIV in Cambodia, Thailand and Viet Nam. Logistic regression was used to assess the association between positive stool culture and TB, and to calculate the incremental yield of stool culture.RESULTS:
A total of 1693 PLHIV were enrolled with a stool culture result. Of 228 PLHIV with culture-confirmed TB from any site, 101 (44%) had a positive stool culture; of these, 91 (90%) had pulmonary TB (PTB). After adjusting for confounding factors, a positive stool culture was associated with smear-negative (odds ratio [OR] 26, 95% confidence interval [CI] 12-58), moderately smear-positive (OR 60, 95%CI 23-159) and highly smear-positive (OR 179, 95%CI 59-546) PTB compared with no PTB. No statistically significant association existed with extra-pulmonary TB compared with no extra-pulmonary TB (OR 2, 95%CI 1-5). The incremental yield of one stool culture above two sputum cultures (5%, 95%CI 3-8) was comparable to an additional sputum culture (7%, 95%CI 4-11).CONCLUSION:
Nearly half of the PLHIV with TB had a positive stool culture that was strongly associated with PTB. Stool cultures may be used to diagnose TB in PLHIV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Tuberculosis Pulmonar
/
Infecciones por VIH
/
Heces
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos