Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
Chem Commun (Camb)
; 49(67): 7397-9, 2013 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-23863995
ABSTRACT
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
Estilbenos
/
MicroARNs
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania
