Hipoglucemiantes/química; Insulina/química; Nylons/química; Poliésteres/química; Administración Oral; Animales; Arginina/química; Disponibilidad Biológica; Diabetes Mellitus Experimental; Hipoglucemiantes/administración & dosificación; Hipoglucemiantes/farmacocinética; Insulina/administración & dosificación; Insulina/farmacocinética; Leucina/química; Lisina/química; Masculino; Microesferas; Ratas; Ratas Wistar

Arg-PEA; Blend microspheres; CLSM; DMA; DMF; DMSO; EE; ESEM; FITC; GI; L0.2; L0.2­30A; N,N-dimethylformamide; Oral insulin delivery; P(MAA-g-EG); PEA; PEA-COOH; PEA-COOH with 20% (molar content) of leucine-based monomer; Poly(ester amide); S/O/O; SC; SDS; SEM; STZ; Span83; arginine-based poly(ester amide); blend microspheres containing 30% Arg-PEA and 70% L0.2 by weight; dimethyl acetamide; dimethyl sulfoxide; encapsulation efficiency; environmental scanning electron microscopy; fluorescein isothiocyanate; gastrointestinal; laser scanning confocal microscopy; pH sensitivity; poly(ester amide); poly(ester amide) with pendant COOH groups; poly(methacrylic-g-ethylene glycol); scanning electron microscopy; sodium dodecyl sulphate; solid-in-oil-in-oil; sorbitan sesquioleate; streptozotocin; subcutaneous