Triterpenoids and steroids with cytotoxic activity from Emmenopterys henryi.
Planta Med
; 79(14): 1356-61, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23881457
ABSTRACT
Two new ursane-type triterpenoids, 3ß,19α,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3ß,19α,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3ß,12ß-dihydroxy-5α-pregnane-14,16-dien-20-one (9) and 12ß-hydroxy-5α-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 µM.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pregnanos
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Triterpenos
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Extractos Vegetales
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Rubiaceae
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Fitoterapia
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Neoplasias
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Planta Med
Año:
2013
Tipo del documento:
Article