How integrins control breast biology.
Curr Opin Cell Biol
; 25(5): 633-41, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23886475
ABSTRACT
This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mama
/
Integrinas
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido