The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
J Exp Med
; 210(9): 1711-28, 2013 Aug 26.
Article
en En
| MEDLINE
| ID: mdl-23897983
ABSTRACT
Tumor-infiltrating immune cells can be conditioned by molecules released within the microenvironment to thwart antitumor immune responses, thereby facilitating tumor growth. Among immune cells, neutrophils play an important protumorigenic role by favoring neoangiogenesis and/or by suppressing antitumor immune responses. Tumor-derived oxysterols have recently been shown to favor tumor growth by inhibiting dendritic cell migration toward lymphoid organs. We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X receptor (LXR)-independent, CXCR2-dependent manner, thus favoring tumor growth by promoting neoangiogenesis and immunosuppression. We demonstrate that interfering with the oxysterol-CXCR2 axis delays tumor growth and prolongs the overall survival of tumor-bearing mice. These results identify an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esteroles
/
Transducción de Señal
/
Receptores de Interleucina-8B
/
Neoplasias
/
Neutrófilos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia