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The effect of antiretrovirals on Plasmodium falciparum liver stages.
Hobbs, Charlotte V; De La Vega, Patricia; Penzak, Scott R; Van Vliet, Jillian; Krzych, Urszula; Sinnis, Photini; Borkowsky, William; Duffy, Patrick E.
Afiliación
  • Hobbs CV; NIH/NIAID/Laboratory of Malaria Immunology and Vaccinology, Rockville, MD 20852, USA. charlotte.hobbs@nih.gov
AIDS ; 27(10): 1674-7, 2013 Jun 19.
Article en En | MEDLINE | ID: mdl-23907270
HIV and malaria overlap geographically, but the full impact of different antiretrovirals on malaria remains poorly understood. We examined the antimalarial activity of the HIV protease inhibitors lopinavir and saquinavir and the non-nucleoside reverse transcriptase inhibitor nevirapine on Plasmodium falciparum liver stages. Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results might have implications for eradication efforts.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Inhibidores de la Proteasa del VIH / Inhibidores de la Transcriptasa Inversa / Hígado Límite: Humans Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Inhibidores de la Proteasa del VIH / Inhibidores de la Transcriptasa Inversa / Hígado Límite: Humans Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido