T-cell homeostasis in pediatric multiple sclerosis: old cells in young patients.
Neurology
; 81(9): 784-92, 2013 Aug 27.
Article
en En
| MEDLINE
| ID: mdl-23911752
ABSTRACT
OBJECTIVE:
To assess pediatric patients with multiple sclerosis (MS) for early signs of homeostatic and functional abnormalities in conventional (Tcon) and regulatory T cells (Treg).METHODS:
We studied the composition of the peripheral T-cell compartment and Treg function in a cross-sectional study with 30 pediatric MS (pMS) patients by multicolor flow cytometry and proliferation assays. Data were compared to those obtained from adult patients (n = 26) and age-matched control donors (n = 67).RESULTS:
Proportions of naive T cells were 10%-20% higher in children than in adults, reflecting the age-related decline. pMS patients, however, had clearly lower numbers of naive T cells, among them recent thymic emigrants (RTE), whereas percentages of memory T cells were increased. In the Treg compartment, reduced RTE numbers coincided with markedly dampened suppressive capacities of total Treg. These homeostatic changes in circulating T cells precisely paralleled the pattern seen in adult MS. As in adults, treatment with immunomodulatory drugs attenuated these alterations.CONCLUSION:
The homeostatic changes detected in the T-cell compartment in pMS are similar to those in adult-onset disease. With ratios between naive and memory T-cell subsets matching those of 20- to 30-years-older controls, signs of early thymic involution are already found in pMS, suggesting that an intrinsic compromise in thymic-dependent T-cell neogenesis might contribute to MS pathogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Subgrupos de Linfocitos T
/
Homeostasis
/
Memoria Inmunológica
/
Esclerosis Múltiple
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
Neurology
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania