Role of nuclear localization of PSMB1 in transcriptional activation.
Biosci Biotechnol Biochem
; 77(8): 1785-7, 2013.
Article
en En
| MEDLINE
| ID: mdl-23924720
ABSTRACT
The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación Transcripcional
/
Complejo de la Endopetidasa Proteasomal
/
Diabetes Mellitus Tipo 2
/
Proteínas Plasmáticas de Unión al Retinol
Límite:
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2013
Tipo del documento:
Article