Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.
J Virol
; 87(20): 11300-3, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23926347
ABSTRACT
Influenza A viruses circulating in humans from â¼1950 to â¼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Mutagénesis Insercional
/
Proteínas no Estructurales Virales
/
Evolución Molecular
/
Gripe Humana
/
Subtipo H3N2 del Virus de la Influenza A
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania