The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients.

Wong, D R; Pierik, M; Seinen, M L; van Bodegraven, A A; Gilissen, L P L; Bus, P; Bakker, J A; Masclee, A A M; Neef, C; Engels, L G J B; Hooymans, P M

Wong, D R; Pierik, M; Seinen, M L; van Bodegraven, A A; Gilissen, L P L; Bus, P; Bakker, J A; Masclee, A A M; Neef, C; Engels, L G J B; Hooymans, P M.

Afiliación

Wong DR; Department of Clinical Pharmacy & Toxicology, Orbis Medical Centre, Sittard, The Netherlands. Electronic address: d.wong@orbisconcern.nl.
Pierik M; Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands.
Seinen ML; Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands.
van Bodegraven AA; Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands.
Gilissen LP; Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.
Bus P; Department of Gastroenterology, Laurentius Hospital, Roermond, The Netherlands.
Bakker JA; Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Masclee AA; Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands.
Neef C; Department of Clinical Pharmacy & Toxicology, University Hospital Maastricht, Maastricht, The Netherlands; Department of Toxicology, Maastricht University, CAPHRI School for Public Health and Primary Care, Maastricht, The Netherlands.
Engels LG; Department of Gastroenterology, Orbis Medical Centre, Sittard, The Netherlands.
Hooymans PM; Department of Clinical Pharmacy & Toxicology, Orbis Medical Centre, Sittard, The Netherlands.

J Crohns Colitis ; 8(2): 120-8, 2014 Feb.

Article en En | MEDLINE | ID: mdl-23932783

Asunto(s)

Antiinflamatorios no Esteroideos/farmacología; Anticuerpos Monoclonales Humanizados/farmacología; Azatioprina/metabolismo; Enfermedad de Crohn/metabolismo; Inmunosupresores/metabolismo; Adalimumab; Adolescente; Adulto; Antiinflamatorios no Esteroideos/uso terapéutico; Anticuerpos Monoclonales Humanizados/uso terapéutico; Azatioprina/farmacocinética; Azatioprina/uso terapéutico; Proteína C-Reactiva/metabolismo; Enfermedad de Crohn/tratamiento farmacológico; Interacciones Farmacológicas; Quimioterapia Combinada; Eritrocitos/enzimología; Femenino; Nucleótidos de Guanina/sangre; Humanos; Hipoxantina Fosforribosiltransferasa/sangre; Inmunosupresores/farmacocinética; Inmunosupresores/uso terapéutico; Masculino; Metiltransferasas/sangre; Persona de Mediana Edad; Estudios Prospectivos; Pirofosfatasas/sangre; Índice de Severidad de la Enfermedad; Tioinosina/análogos & derivados; Tioinosina/sangre; Tionucleótidos/sangre; Adulto Joven; Inosina Trifosfatasa

Palabras clave

6-MMPR; 6-MP; 6-TGN; 6-TGTP; 6-methylmercaptopurine ribonucleotides; 6-thioguanine nucleotides; 6-thioguanine triphosphate; 95% CI; 95% confidence interval; AZA; Adalimumab; Azathioprine; C-reactive protein; CD; CDAI; CRP; Crohn's disease; Crohn's disease activity index; Drug interaction; HGPRT; HPLC; IBD; IMP; ITPase; MCV; Mercaptopurine; RBC; TDM; TPMT; Therapeutic drug monitoring; UC; azathioprine; high performance liquid chromatography; hypoxanthine-guanine phosphoribosyl transferase; inflammatory bowel disease; inosine monophosphate; inosine triphosphate pyrophosphatase; mean corpuscular volume; mercaptopurine; red blood cells; therapeutic drug monitoring; thiopurine S-methyltransferase; ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azatioprina / Enfermedad de Crohn / Antiinflamatorios no Esteroideos / Anticuerpos Monoclonales Humanizados / Inmunosupresores Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Crohns Colitis Asunto de la revista: GASTROENTEROLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

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